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MnO2-armored human embryonic stem cell exosomes delay intervertebral disc degeneration via synergistic antioxidant defense and regenerative signal delivery
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DOI：10.1016/j.mtbio.2026.103515.png)
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Abstract
En 中文
The oxidative and inflammatory microenvironment impairs the regeneration and homeostasis of nucleus pulposus cells. This microenvironment is characterized by high levels of reactive oxygen species (ROS), mitochondrial dysfunction, and NLRP3 inflammasome-induced pyroptosis. These changes accelerate cellular senescence and disrupt the metabolic homeostasis of the extracellular matrix (ECM). Exosomes derived from human embryonic stem cells (hESCs) hold great potential for regeneration and inflammation control but lack inherent antioxidant protection. In the highly oxidative microenvironment of degenerated intervertebral discs, these exosomes degrade rapidly, which significantly limits their therapeutic efficacy. To address this issue, we developed a manganese dioxide nanoplate-armored exosome system (hESC-Exos@MnO2).
Keywords:
Intervertebral disc degeneration
hESC-derived exosomes
ROS scavenging
Pyroptosis
Cell senescence
Extracellular matrix regeneration
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