Model-Based Control in Dimensional Psychiatry

Valerie Voon

doi:10.1016/j.biopsych.2017.04.006

2017-09-01

PRE

DOI：10.1016/j.biopsych.2017.04.006

原文链接

原文求助

摘要

En 中文

We use parallel interacting goal-directed and habitual strategies to make our daily decisions. The arbitration between these strategies is relevant to inflexible repetitive behaviors in psychiatric disorders. Goal-directed control, also known as model-based control, is based on an affective outcome relying on a learned internal model to prospectively make decisions. In contrast, habit control, also known as model-free control, is based on an integration of previous reinforced learning autonomous of the current outcome value and is implicit and more efficient but at the cost of greater inflexibility. The concept of model-based control can be further extended into pavlovian processes. Here we describe and compare tasks that tap into these constructs and emphasize the clinical relevance and translation of these tasks in psychiatric disorders. Together, these findings highlight a role for model-based control as a transdiagnostic impairment underlying compulsive behaviors and representing a promising therapeutic target.

Keyword:

Addictions

Binge eating

Compulsivity

Computational psychiatry

Goal-directed control

Habit

Model-based control

Obsessive-compulsive disorder

AI总结

对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。

期刊

Biological Psychiatry

IF:

论文数:

1.5W

被引数:

4.0W

机构

Berlin Institute of Health

学者数:

3.9W

论文数: 3.0W

被引数: 6.6K

Charite Universitatsmedizin Berlin

学者数:

1.6W

论文数: 1.3W

被引数: 29

University of Cambridge

学者数:

7.7W

论文数: 7.1W

被引数: 13.7W

Humboldt University of Berlin

学者数:

3.2W

论文数: 2.7W

被引数: 47

查看更多机构

引用论文

Efficiency and Emissions Mapping of a Light Duty Diesel - Natural Gas Engine Operating in Conventional Diesel and RCCI Modes

SAE Technical Paper Series

IF0

2016-10-17

PREAI

Ehsan Ansari; Kamran Poorghasemi; Behrouz Khoshbakht Irdmousa; Mahdi Shahbakhti; Jeffrey Naber

Systematic review of the evidence for Trails B cut-off scores in assessing fitness-to-drive

Canadian Geriatrics Journal

IF0

2013-06-17

OAAI

Mononita Roy; Frank Molnar

Dopamine Enhances Model-Based over Model-Free Choice Behavior 多巴胺增强了基于模型的无模型选择行为

NEURON

IF15

2012-08-01

198

OAAI

Wunderlich, Klaus; Smittenaar, Peter; Dolan, Raymond J.

Model-Based Influences on Humans' Choices and Striatal Prediction Errors 基于模型对人类选择和纹状体预测误差的影响

NEURON

IF15

2011-03-01

1.2K

OAAI

Daw, Nathaniel D.; Gershman, Samuel J.; Seymour, Ben; Dayan, Peter; Dolan, Raymond J.

Motivation and value influences in the relative balance of goal-directed and habitual behaviours in obsessive-compulsive disorder

TRANSLATIONAL PSYCHIATRY

IF6.2

2015-11-03

OAAI

Voon, V.; Baek, K.; Enander, J.; Worbe, Y.; Morris, L. S.; Harrison, N. A.; Robbins, T. W.; Rueck, C.; Daw, N.

Disorders of compulsivity: a common bias towards learning habits

MOLECULAR PSYCHIATRY

IF10.1

2014-05-20

444

OAAI

Voon, V.; Derbyshire, K.; Ruck, C.; Irvine, M. A.; Worbe, Y.; Enander, J.; Schreiber, L. R. N.; Gillan, C.; Fineberg, N. A.; Sahakian, B. J.; Robbins, T. W.; Harrison, N. A.; Wood, J.; Daw, N. D.; Dayan, P.; Grant, J. E.; Bullmore, E. T.

Fronto-striatal organization: Defining functional and microstructural substrates of behavioural flexibility 额纹状体组织: 定义行为灵活性的功能和微观结构基础

CORTEX

IF3.3

2016-01-01

169

OAAI

Morris, Laurel S.; Kundu, Prantile; Dowell, Nicholas; Mechelmans, Daisy J.; Favre, Pauline; Irvine, Michael A.; Robbins, Trevor W.; Daw, Nathaniel; Bullmore, Edward T.; Harrison, Neil A.; Voon, Valerie

Impaired Flexible Reward-Based Decision-Making in Binge Eating Disorder: Evidence from Computational Modeling and Functional Neuroimaging

NEUROPSYCHOPHARMACOLOGY

IF7.1

2016-06-15

OAAI

Reiter, Andrea M. F.; Heinze, Hans-Jochen; Schlagenhauf, Florian; Deserno, Lorenz

The involuntary nature of binge drinking: goal directedness and awareness of intention 狂饮的非自愿性质: 目标导向和意图意识

ADDICTION BIOLOGY

IF2.6

2017-04-16

OAAI

Donamayor, Nuria; Strelchuk, Daniela; Baek, Kwangyeol; Banca, Paula; Voon, Valerie