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Model-based real-time optimization in continuous pharmaceutical manufacturing
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DOI：10.1016/j.compchemeng.2024.108915.png)
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摘要
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In this work, real-time optimization (RTO) schemes are proposed and applied on a continuous pharmaceutical manufacturing process which consists of three units: synthesis unit, hot melt extrusion unit and direct compaction line. The developed RTO strategies calculate the operating conditions by optimizing the considered objective functions while satisfying the specific constraints. Moreover, the RTO schemes can cope with intentional changes in the process and unintentional changes such as disturbances. Results from simulations and experiments are presented in this work. An advantageous performance is achieved when using the developed schemes.
Keyword:
Real-time optimization
Continuous pharmaceutical manufacturing
Direct compaction
Continuous synthesis
期刊
C
IF:
3.9
论文数:
8.1K
被引数:
1.7W
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引用论文
Process analysis and optimization of continuous pharmaceutical manufacturing using flowsheet models
OAAI
OAAI分享收藏Autonomous Multi-Step and Multi-Objective Optimization Facilitated by Real-Time Process Analytics.png)
ADVANCED SCIENCE
OAAI
ADVANCED SCIENCEIF14.1
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