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Modeling cortisol rhythms in a population-based study
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DOI：10.1016/j.psyneuen.2005.02.003.png)
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The aim of these analyses was to develop and describe easily implementable, yet information rich, approaches for analysis of the temporal profile of cortisol in human populations. A typical waking profile of cortisol in a sample of women aged 15-44 was parameterized by a piecewise Linear regression model, implemented as a mixed model to accommodate repeated observations among individuals. The model was extended to distinguish characteristic cortisol profiles of obese women from those of non-obese women. Sharp inflection points for the diurnal profile of cortisol were noted at 30 and 75 min past awakening. Obese women showed a slight tendency to have a less sharply rising and declining response to awakening than non-obese women. (c) 2005 Elsevier Ltd. All rights reserved.
Keyword:
cortisol
diurnal profile
regression splines
mixed models
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