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Modelling hormonal response and development
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DOI：10.1016/j.tplants.2014.02.004.png)
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As our knowledge of the complexity of hormone homeo-stasis, transport, perception, and response increases, and their outputs become less intuitive, modelling is set to become more important. Initial modelling efforts have focused on hormone transport and response pathways. However, we now need to move beyond the network scales and use multicellular and multiscale modelling approaches to predict emergent properties at different scales. Here we review some examples where such approaches have been successful, for example, auxin-cytokinin crosstalk regulating root vascular development or a study of lateral root emergence where an iterative cycle of modelling and experiments lead to the identification of an overlooked role for PIN3. Finally, we discuss some of the remaining biological and technical challenges.
Keyword:
modelling
hormone signalling
systems biology
multiscale modelling.
期刊
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20.8
论文数:
3.8K
被引数:
3.2W
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