.png){kind=icon}
返回
Modelling the Yeast Interactome
.png){kind=icon}
OA
AI
DOI：10.1038/srep04273.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
The topology behind biological interaction networks has been studied for over a decade. Yet, there is no definite agreement on the theoretical models which best describe protein-protein interaction (PPI) networks. Such models are critical to quantifying the significance of any empirical observation regarding those networks. Here, we perform a comprehensive analysis of yeast PPI networks in order to gain insights into their topology and its dependency on interaction-screening technology. We find that: (1) interaction-detection technology has little effect on the topology of PPI networks; (2) topology of these interaction networks differs in organisms with different cellular complexity (human and yeast); (3) clear topological difference is present between PPI networks, their functional sub-modules, and their inter-functional linkers;(4) high confidence PPI networks have more geometrical topology compared to predicted, incomplete, or noisy PPI networks; and (5) inter-functional linker proteins serve as mediators in signal transduction, transport, regulation and organisational cellular processes.
Keyword:
PROTEIN-INTERACTION NETWORKS
FUNCTIONAL MODULES
DATABASE
ORGANIZATION
COMPLEXES
MAP
LANDSCAPE
DYNAMICS
BIOLOGY
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
3.9
论文数:
28.0W
被引数:
83.5W
机构
引用论文
.png){kind=icon}
Increased prevalence and titer of Epstein‐Barr virus antibodies in patients with multiple sclerosis
PREAI
分享收藏
查看更多内容