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Modification of proportion sensitivity testing method for ethionamide
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DOI：10.1007/s11274-013-1255-y.png)
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摘要
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Standardized methodology for drug susceptibility testing of second line drugs is vital for treatment of multi/extensively drug resistant tuberculosis. Discrepancy between laboratory methods and clinical interpretation is well established for bacteriostatic drugs such as ethionamide. Optimization of the standard proportion sensitivity testing (PST) method for ethionamide was under taken in 235 Mycobacterium tuberculosis isolates from new and previously treated pulmonary tuberculosis patients. An additional higher concentration of 57 mu g/ml was evaluated against at the standard 40 mu g/ml concentration in PST method. Performance parameters and agreement between the two drug concentrations was higher indicating the efficiency of PST method at its present format at 40 mu g/ml and additional higher concentration of 57 mu g/ml as an alternative when required.
Keyword:
Drug resistance
Ethionamide
Mycobacterium tuberculosis
MIC method
Proportion sensitivity testing
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