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Modulating Peptide Self-Assembly via Triblock Chiral Patterning

delete2025-06-05
delete0
PRE
AI
C
Conor L. O’Neill
J
Jonathan Fascetti
Z
Zoe Clapacs
L
Lauren K. Kaplita
C
Chih-Yun Liu
D
Darren Kim
M
Mark A. White
J
Jai S. Rudra *
DOI：10.1002/chem.202404603delete
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摘要

摘要

En 中文
肽自组装体的超结构完整性由一系列复杂的内聚相互作用驱动，这些相互作用引导并维持层级有序性。对原子排列看似微小的改变，如用D-氨基酸进行取代，可显著影响组装潜能和最终结构。当一级序列由连续相同的基序构成时，可通过根据这些基本单元划分手性反转来生成“块状异手性”肽。在本工作中，我们针对模型β-折叠形成肽KFE12（Ac-(FKFE)3-NH2）的所有三嵌段手性模式进行了组合探索。对四种所得对映异构体对的分析表明，每种均产生独特的形貌，范围从最小4 nm宽的纤维到微米级半结构化聚集物。我们对这些变体的研究表明，其兼具保守和发散的层级特征，反映了持久基础力与块状分子内手性界面独特空间效应之间复杂的相互作用。
Keyword:
chirality
peptide self-assembly
supramolecular morphology

期刊

C
Chemistry - A European Journal
IF:
3.7
论文数:
1.1K
被引数:
20

机构

U
University of Texas Medical Branch
学者数:
941
论文数: 323
被引数: 1
W
washington university in st. louis
学者数:
672
论文数: 290
被引数: 1
引用论文

引用论文

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