Modulating salience network connectivity through olfactory nerve stimulation

doi:10.1038/s41398-025-03500-6

2025-08-21

Carina Heller *

Maria Geisler

Nicolas L Mayer

Annabelle Thierfelder

Martin Walter

Thomas Hummel

Ilona Croy

DOI：10.1038/s41398-025-03500-6

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抑郁与大脑默认模式网络（DMN）中功能连接的减弱及其与默认模式网络（DMN）交互作用的增强相关。改变这种临床模式具有挑战性。利用从嗅觉处理区域到默认模式网络（DMN）的直接神经通路，我们探究了嗅觉黏膜电刺激对脑连接的影响。在一项随机、盲法、受试者内设计中，45名健康个体接受了嗅觉或三叉神经刺激，随后进行静息态fMRI扫描。嗅觉刺激导致默认模式网络（DMN）与梨状皮质——一个初级嗅觉结构——之间的功能连接显著增加。重要的是，这种刺激增强了默认模式网络（DMN）内的功能连接，并削弱了默认模式网络（DMN）与DMN之间的连接。这些发现表明，嗅觉刺激可能调节与抑郁相关的连接模式，提供了一种新型潜在微创治疗策略。然而，由于这些结果来自健康人群，需要进一步研究以评估其在抑郁患者中的有效性。

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Translational Psychiatry

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department of psychosomatic medicine and psychotherapy

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Department of Clinical Psychology

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