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Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis

delete2026-07-21
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PRE
AI
A
Adrien Grimont
D
David J. Falvo
W
Whitney J. Sisso
F
Francisco dos Santos
C
Christopher W. Chan
P
Paul Zumbo
W
William B. Fall
K
Katherine R. Ferrick
G
Grace Pan
M
Megan Cleveland
T
Tomer M. Yaron
A
Alexa Osterhoudt
Y
Yinuo Meng
M
Maria Paz Zafra
A
Andre F. Rendeiro
E
Erika Hissong
R
Rhonda K. Yantiss
D
Doron Betel
M
Mark A. Magnuson
S
Steven D. Leach
DOI：10.1016/j.devcel.2026.06.016delete
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Abstract

Abstract

En 中文
• Inflammation induces lineage reversion in pancreatic acinar cells • Enhancer rewiring, initiated by injury, is co-opted by KrasG12D in tumorigenesis • KrasG12V/R are not able to sustain enhancer reprogramming and neoplastic commitment • Deficient KrasG12R EGFR and RAC1 signaling are rescued by enforced AKT activation

Journal

Developmental Cell cover
Developmental Cell
IF:
8.7
Papers:
6.3K
Citations:
3.4W

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