Molnupiravir: coding for catastrophe

doi:10.1038/s41594-021-00657-8

2021-09-13

115

Brandon Malone

Elizabeth A. Campbell *

DOI：10.1038/s41594-021-00657-8

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摘要

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Molnupiravir, a wide-spectrum antiviral that is currently in phase 2/3 clinical trials for the treatment of COVID-19, is proposed to inhibit viral replication by a mechanism known as 'lethal mutagenesis'. Two recently published studies reveal the biochemical and structural bases of how molnupiravir disrupts the fidelity of SARS-CoV-2 genome replication and prevents viral propagation by fostering error accumulation in a process referred to as 'error catastrophe'.

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Nature Structural and Molecular Biology

IF:

10.1

论文数:

4.8K

被引数:

2.8W

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rockefeller university

学者数:

6.6K

论文数: 4.9K

被引数: 15

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