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Monitoring and quantifying replication fork dynamics with high-throughput methods
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DOI：10.1038/s42003-024-06412-1.png)
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摘要
En 中文
Before each cell division, eukaryotic cells must replicate their chromosomes to ensure the accurate transmission of genetic information. Chromosome replication involves more than just DNA duplication; it also includes chromatin assembly, inheritance of epigenetic marks, and faithful resumption of all genomic functions after replication. Recent progress in quantitative technologies has revolutionized our understanding of the complexity and dynamics of DNA replication forks at both molecular and genomic scales. Here, we highlight the pivotal role of these novel methods in uncovering the principles and mechanisms of chromosome replication. These technologies have illuminated the regulation of genome replication programs, quantified the impact of DNA replication on genomic mutations and evolutionary processes, and elucidated the mechanisms of replication-coupled chromatin assembly and epigenome maintenance. This review discusses the recent methodological advances in monitoring eukaryotic chromosome replication.
Keyword:
DNA-REPLICATION
GENOME-WIDE
SYMMETRIC INHERITANCE
METHYLATION
PROPAGATION
MAINTENANCE
MECHANISMS
INITIATION
PROTEINS
CAPTURE
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期刊
IF:
5.1
论文数:
1.0W
被引数:
3.2W
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