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Monocyte activation in multiple sclerosis

delete1998-06-01
delete39
PRE
AI
A
Anthony T. Reder
K
Kürşad Genç
P
Paul V Byskosh
A
A.M. Porrini
DOI：10.1177/135245859800400314delete
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摘要

摘要

En 中文
Monocytes, macrophages, and microglia have a central role in the CNS inflammation of MS. Monocytes are important in the earliest events in MS. Peripheral blood monocytes secrete prostaglandins before MS attacks. During clinical activity monocyte activation markers increase and IL-1 and TNF-alpha levels ore elevated. Other monocyte products such as IL-10 reduce inflammation. IL-10 mRNA in MNC is increased during stable disease. Manipulation of monokine secretion and expression of monocyte surface proteins ore reasonable approaches for immune therapy of MS.
Keyword:
monocyte
microglia
multiple sclerosis
CD80
IFN-beta
IFN-gamma
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期刊

Multiple Sclerosis Journal 封面图
Multiple Sclerosis Journal
IF:
5
论文数:
5.4K
被引数:
1.4W

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