返回
摘要
En 中文
Polarized epithelial cells create tightly packed arrays of microvilli in their apical membrane, but the fate of these microvilli is relatively unknown when epithelial cell polarity is lost during wound healing. In this issue, Klingner et al. (2014. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201402037) show that, when epithelial cells become subconfluent, actomyosin contractions locally within the apical cortex cause their microvilli to become motile over the dorsal/apical surface. Their unexpected observations may have implications for epithelial responses in wound healing and disease.
Keyword:
MESENCHYMAL TRANSITION
ERM PROTEINS
CELLS
CORTEX
MORPHOGENESIS
FILOPODIA
MEMBRANE
DRIVEN
AI总结
对已上传原文的论文进行重点信息的提取,主要内容包括:简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
6.4
论文数:
1.2W
被引数:
5.7W
机构
暂无机构信息
引用论文
BMP-7 counteracts TGF-β1-induced epithelial-to-mesenchymal transition and reverses chronic renal injuryBMP-7对抗tgf-β1诱导的上皮-间质转化并逆转慢性肾损伤
NATURE MEDICINE
IF50

