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MPC1 regulates endotoxin tolerance of macrophages through mitochondrial oxidative stress resistance

delete2026-04-26
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PRE
AI
刘
刘艳 (Yan Liu)
F
Feng Qi
H
Hongrui Zeng
D
Dandan Huang
W
Wenfeng Zhang
Y
Yifan Zhang
J
Jianping Gong
L
Lunjian Xiang
Z
Zhujun Yi *
DOI：10.1016/j.cellimm.2026.105111delete
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Abstract

Abstract

En 中文
• MPC1 is a negative regulator of LPS-mediated inflammatory response. • Overexpression of MPC1 does not promote the formation of endotoxin tolerance. • Mitochondrial oxidative stress resistance promotes endotoxin tolerance. • MPC1 regulates mitochondrial oxidative stress resistance and endotoxin tolerance through the SIRT3/SOD2 axis.
Keywords:
MPC1
endotoxin tolerance
mitochondrial oxidative stress
SIRT3/SOD2 axis
macrophages

Journal

Cellular Immunology cover
Cellular Immunology
IF:
2.9
Papers:
3.6K
Citations:
6.1K

Organization

C
Chongqing Medical University
Scholars:
5.9K
Papers: 1.5K
Citations: 2.8W
C
chongqing university
Scholars:
1.0W
Papers: 3.9K
Citations: 1
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