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Multi-Objective-Based Radiomic Feature Selection for Lesion Malignancy Classification

delete2020-01-01
delete28
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OA
AI
Z
Zhiguo Zhou
李
李淑龙 (Shulong Li)
G
Genggeng Qin
M
Michael R. Folkert
S
Steve Jiang
王
王静 (Jing Wang) *
DOI:10.1109/JBHI.2019.2902298delete
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摘要

摘要

En 中文
Objective: accurately classifying the malignancy of lesions detected in a screening scan is critical for reducing false positives. Radiomics holds great potential to differentiate malignant from benign tumors by extracting and analyzing a large number of quantitative image features. Since not all radiomic features contribute to an effective classifying model, selecting an optimal feature subset is critical. Methods: this work proposes a new multi-objective based feature selection (MO-FS) algorithm that considers sensitivity and specificity simultaneously as the objective functions during feature selection. For MO-FS, we developed a modified entropy-based termination criterion that stops the algorithm automatically rather than relying on a preset number of generations. We also designed a solution selection methodology for multi-objective learning that uses the evidential reasoning approach (SMOLER) to automatically select the optimal solution from the Pareto-optimal set. Furthermore, we developed an adaptive mutation operation to generate the mutation probability in MO-FS automatically. Results: we evaluated the MO-FS for classifying lung nodule malignancy in low-dose CT and breast lesion malignancy in digital breast tomosynthesis. Conclusion: the experimental results demonstrated that the feature set selected by MO-FS achieved better classification performance than features selected by other commonly used methods. Significance: the proposed method is general and more effective radiomic feature selection strategy.
Keyword:
Feature extraction
Lesions
Entropy
Informatics
Sociology
Statistics
Linear programming
Radiomics
lesion malignancy classification
feature selection
multi-objective evolutionary algorithm
evidential reasoning
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期刊

IEEE Journal of Biomedical and Health Informatics 封面图
IEEE Journal of Biomedical and Health Informatics
IF:
6.8
论文数:
4.6K
被引数:
2.0W

机构

U
university of texas southwestern medical center dallas
学者数:
1.8W
论文数: 1.4W
被引数: 28
U
university of texas system
学者数:
18.5W
论文数: 15.6W
被引数: 210
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引用论文

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