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Multi-omics suggests a pathogenic pathway linking gut dysbiosis, arachidonic acid, and hippocampal ferroptosis in central fatigue
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DOI:10.1016/j.lfs.2026.124609.png)
Abstract
En 中文
Central fatigue is a debilitating condition with unclear pathogenesis and limited treatments. Emerging evidence implicates the gut-brain axis in neurological disorders, but its role in central fatigue remains unexplored. This study aimed to elucidate the gut-brain axis in central fatigue via multi-omics and identify potential therapeutic targets.
Keywords:
Central fatigue
Gut microbiota
Serum metabolomics
Transcriptomics
Arachidonic acid
Ferroptosis
Journal
IF:
5.1
Papers:
1.7W
Citations:
4.7W
