.png){kind=icon}
返回
Multiobjective Optimization Applied to the Eradication of Persistent Pathogens
.png){kind=icon}
OA
AI
DOI：10.1109/TEVC.2010.2040181.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
In scenarios such as therapeutic modeling or pest control, one aims to suppress infective agents or maximize crop yields while minimizing the side-effects of interventions, such as cost, environmental impact, and toxicity. Here, we consider the eradication of persistent microbes (e. g., Escherichia coli, multiply resistant Staphylococcus aureus (MRSA-superbug), Mycobacterium tuberculosis, Pseudomonas aeruginosa) through medication. Such microbe populations consist of metabolically active and metabolically inactive (persistent) subpopulations. It turns out that, for efficient medication strategies, the two goals, eradication of active bacteria on one hand and eradication of inactive bacteria on the other, are in conflict. Using multiobjective optimization, we obtain a survey of the full spectrum of best solutions. We find that, if treatment time is limited and the total medication dose is constant, the application of the medication should be concentrated both at the beginning and end of the treatment. If the treatment time is increased, the medication should become increasingly spread out over the treatment period until it is uniformly spread over the entire period. The transition between short and long overall treatment times sees optimal medication strategies clustered into groups.
Keyword:
Biochemistry
biological systems
biology
biomedical
chemistry
computational bioinformatics
computational intelligence
ecology
evolutionary biology
evolvable hardware
game theory
mathematics
期刊
IF:
12
论文数:
1.9K
被引数:
2.4W
机构
引用论文
.png){kind=icon}
分享收藏
查看更多内容