.png){kind=icon}
返回
Multiphase Complex Coacervate Droplets
.png){kind=icon}
OA
AI
DOI：10.1021/jacs.9b11468.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Liquid-liquid phase separation plays an important role in cellular organization. Many subcellular condensed bodies are hierarchically organized into multiple coexisting domains or layers. However, our molecular understanding of the assembly and internal organization of these multicomponent droplets is still incomplete, and rules for the coexistence of condensed phases are lacking. Here, we show that the formation of hierarchically organized multiphase droplets with up to three coexisting layers is a generic phenomenon in mixtures of complex coacervates, which serve as models of chargedriven liquid-liquid phase separated systems. We present simple theoretical guidelines to explain both the hierarchical arrangement and the demixing transition in multiphase droplets using the interfacial tensions and critical salt concentration as inputs. Multiple coacervates can coexist if they differ sufficiently in macromolecular density, and we show that the associated differences in critical salt concentration can be used to predict multiphase droplet formation. We also show that the coexisting coacervates present distinct chemical environments that can concentrate guest molecules to different extents. Our findings suggest that condensate immiscibility may be a very general feature in biological systems, which could be exploited to design self-organized synthetic compartments to control biomolecular processes.
Keyword:
PHASE-SEPARATION
TRANSITIONS
PROTEINS
MODEL
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
15.6
论文数:
20.0W
被引数:
60.2W
机构
引用论文
Reduction of ischemic spinal cord injury by dextrorphan: Comparison of several methods of administrationDexorphan减少缺血性脊髓损伤: 几种给药方法的比较OAAI
OAAI分享收藏Critical parameters in designing segmented polyurethanes and their effect on morphology and properties: A comprehensive review.png)
PolymerOAAI
PolymerIF0
OAAI分享收藏RNA is a critical element for the sizing and the composition of phase-separated RNA-protein condensatesNATURE COMMUNICATIONSOAAI
NATURE COMMUNICATIONSIF15.7
OAAI分享收藏
查看更多内容