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Multiple sequence alignment modeling: methods and applications

delete2015-11-27
delete127
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OA
AI
M
Maria Chatzou
C
Cedrik Magis
J
Jia‐Ming Chang
C
Carsten Kemena
G
Giovanni Bussotti
I
Ionas Erb
C
Cédric Notredame *
DOI:10.1093/bib/bbv099delete
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摘要

摘要

En 中文
This review provides an overview on the development of Multiple sequence alignment (MSA) methods and their main applications. It is focused on progress made over the past decade. The three first sections review recent algorithmic developments for protein, RNA/DNA and genomic alignments. The fourth section deals with benchmarks and explores the relationship between empirical and simulated data, along with the impact on method developments. The last part of the review gives an overview on available MSA local reliability estimators and their dependence on various algorithmic properties of available methods.
Keyword:
multiple sequence alignments
protein alignments
alignment benchmarks
alignment reliability measures
RNA alignments
DNA alignments
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期刊

Briefings in Bioinformatics 封面图
Briefings in Bioinformatics
IF:
7.7
论文数:
5.8K
被引数:
2.7W

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B
barcelona institute of science & technology
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1.2W
论文数: 9.7K
被引数: 36
P
Pompeu Fabra University
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9.3K
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被引数: 11
C
centre de regulacio genomica (crg)
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1.3K
论文数: 771
被引数: 2
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