Multiple sequence alignment

R. C. Edgar

doi:10.1016/j.sbi.2006.04.004

2006-06-01

366

PRE

R. C. Edgar *

Serafim Batzoglou

DOI：10.1016/j.sbi.2006.04.004

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摘要

En 中文

Multiple sequence alignments are an essential tool for protein structure and function prediction, phylogeny inference and other common tasks in sequence analysis. Recently developed systems have advanced the state of the art with respect to accuracy, ability to scale to thousands of proteins and flexibility in comparing proteins that do not share the same domain architecture. New multiple alignment benchmark databases include PREFAB, SABMARK, OXBENCH and IRMBASE. Although CLUSTALW is still the most popular alignment tool to date, recent methods offer significantly better alignment quality and, in some cases, reduced computational cost.

Keyword:

BENCHMARK

ACCURACY

IMPROVEMENT

ALGORITHM

DIALIGN

CLASSIFICATION

CONSISTENCY

PROTEINS

DATABASE

MUSCLE

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期刊

Current Opinion in Structural Biology

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3.8K

被引数:

1.3W

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