.png){kind=icon}
返回
Multiplexed Bio-detection on an Interferometric Optical Waveguide Assembly
.png){kind=icon}
OA
AI
DOI：10.1002/admi.202400941.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Multiplexed remote bio-detection is demonstrated through an optical waveguide assembly coated with interferometric layers. Image conduits (IC)s, composed of 3012 individual cores, are coated with interferometric layers of tantalum pentoxide (Ta2O5) and silica (SiO2) to transform each core into a sensitive sensor. The spectral response of the IC as a function of refractive index (RI) changes is obtained and compared with the simulated one. The experimental sensitivities and resolutions of individual cores of the waveguide are assessed in remote detection mode by imaging through the optical assembly. For 75% of the cores, a sensitivity better than 510%. RIU-1 (RI Unit) is obtained, corresponding to a resolution better than 7 x 10-4 RIU. Furthermore, the coated face of IC is functionalized with two localized arrays of hundred-micrometer droplets containing two different oligonucleotide (ODN) probes using a polymeric 3D-printed microcantilever. Hybridization of complementary ODN strands is detected for one of the probes, the second being a negative control. Interaction kinetics are monitored in functionalized areas by grouping several cores or on individual cores. Thus, multiplexed bio-detection on the surface of an interferometric waveguide is demonstrated for the first time paving the way for applications in multiplex in situ biosensing, and, ultimately, in vivo endoscopic diagnosis.
Keyword:
biosensor
image conduit
interferometry
multiplex
optical waveguide assembly
remote bio-detection
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
4.4
论文数:
6.7K
被引数:
2.4W
机构
引用论文
Improved Passive Treatment of Acid Mine Drainage in Mushroom Compost Amended with Crab-Shell Chitin
PREAI
分享收藏Multiplexed Optical Fiber Biochemical Sensing Using Cascaded C-Shaped Fabry-Perot Interferometers使用级联C形fabry-perot干涉仪的多路光纤生化传感.png)
IEEE SENSORS JOURNAL
IEEE SENSORS JOURNALIF4.5
PREAI
分享收藏Ultrafast and Multiplexed Bacteriophage Susceptibility Testing by Surface Plasmon Resonance and Phase Imaging of Immobilized Phage MicroarraysCHEMOSENSORS
OAAI
CHEMOSENSORSIF3.7
OAAI分享收藏
查看更多内容