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Multitarget Pharmacological Effects of Lawsone in Mitigating Alzheimer’s Disease
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DOI：10.1016/j.ejphar.2026.178920.png)
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Abstract
En 中文
• Lawsone shows strong binding affinity to NF-κB, c-JNK, AChE, BuChE, and TNF-α • Improves spatial memory in Morris water maze and Y-maze tests • Reduces oxidative stress and neuroinflammation in brain tissue • H&E and Congo red staining reveals reduced neuronal damage and amyloid load. • Down regulates APP, Aβ1-42, Tau, NF-κB, c-JNK, and TNF-α expression • Suppresses Aβ and Tau pathology and preserves neuronal integrity • Lawsone targets amyloidogenic, tauopathic, and inflammatory pathways • Demonstrates potential as a multitarget therapeutic candidate for AD
Keywords:
Lawsone
Alzheimer’s disease
amyloid pathology
tau pathology
neuroinflammation
Journal
IF:
4.7
Papers:
2.3W
Citations:
4.0W
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