.png){kind=icon}
返回
Nanoparticle Toxicology
.png){kind=icon}
OA
AI
DOI：10.1146/annurev-pharmtox-032320-110338.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Nanoparticles from natural and anthropogenic sources are abundant in the environment, thus human exposure to nanoparticles is inevitable. Due to this constant exposure, it is critically important to understand the potential acute and chronic adverse effects that nanoparticles may cause to humans. In this review, we explore and highlight the current state of nanotoxicology research with a focus on mechanistic understanding of nanoparticle toxicity at organ, tissue, cell, and biomolecular levels. We discuss nanotoxicity mechanisms, including generation of reactive oxygen species, nanoparticle disintegration, modulation of cell signaling pathways, protein corona formation, and poly(ethylene glycol)-mediated immunogenicity. We conclude with a perspective on potential approaches to advance current understanding of nanoparticle toxicity. Such improved understanding may lead to mitigation strategies that could enable safe application of nanoparticles in humans. Advances in nanotoxicity research will ultimately inform efforts to establish standardized regulatory frameworks with the goal of fully exploiting the potential of nanotechnology while minimizing harm to humans.
Keyword:
nanoparticles
toxicology
physicochemical properties
anti-PEG antibody
protein corona
ROS
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
暂无期刊信息
机构
引用论文
分享收藏Low risk posed by engineered and incidental nanoparticles in drinking water.png)
NATURE NANOTECHNOLOGY
NATURE NANOTECHNOLOGYIF34.9
PREAI
分享收藏分享收藏On the issue of transparency and reproducibility in nanomedicine关于纳米医学的透明度和可重复性问题NATURE NANOTECHNOLOGYOAAI
NATURE NANOTECHNOLOGYIF34.9
OAAI分享收藏Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivoNATURE NANOTECHNOLOGYOAAI
NATURE NANOTECHNOLOGYIF34.9
OAAI分享收藏
查看更多内容