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Nascent chain folding status modulates ribosome dynamics and mRNA stability through the ribosome-associated chaperone Zuo1
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DOI：10.1016/j.molcel.2026.06.041.png)
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Abstract
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• Zuo1 slows down elongating ribosomes in response to nascent protein misfolding • Zuo1-mediated ribosome slowdown triggers co-translational mRNA decay via Not5 • Zuo1 binding to ribosomes and Ssb chaperones is required for this function • This surveillance mechanism is conserved in human cells
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