.png){kind=icon}
返回
Negative supercoils regulate meiotic crossover patterns in budding yeast
.png){kind=icon}
OA
AI
DOI：10.1093/nar/gkac786.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Interference exists ubiquitously in many biological processes. Crossover interference patterns meiotic crossovers, which are required for faithful chromosome segregation and evolutionary adaption. However, what the interference signal is and how it is generated and regulated is unknown. We show that yeast top2 alleles which cannot bind or cleave DNA accumulate a higher level of negative supercoils and show weaker interference. However, top2 alleles which cannot religate the cleaved DNA or release the religated DNA accumulate less negative supercoils and show stronger interference. Moreover, the level of negative supercoils is negatively correlated with crossover interference strength. Furthermore, negative supercoils preferentially enrich at crossover-associated Zip3 regions before the formation of meiotic DNA double-strand breaks, and regions with more negative supercoils tend to have more Zip3. Additionally, the strength of crossover interference and homeostasis change coordinately in mutants. These findings suggest that the accumulation and relief of negative supercoils pattern meiotic crossovers.
Keyword:
DOUBLE-STRAND-BREAK
DNA TOPOISOMERASE-II
CROSSING-OVER
CHIASMA INTERFERENCE
CHROMOSOME SYNAPSIS
HOMEOSTASIS
RESISTANCE
COMPLEX
IDENTIFICATION
REPLICATION
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
13.1
论文数:
3.6W
被引数:
29.0W
机构
引用论文
Effect of unpleasant loud noise on hippocampal activities during picture encoding: An fMRI study
PREAI
分享收藏Inhibition of Vascular Smooth Muscle Cell Proliferation by Gentiana lutea Root Extracts.png)
PLoS ONE
OAAI
PLoS ONEIF0
OAAI分享收藏Refined spatial temporal epigenomic profiling reveals intrinsic connection between PRDM9-mediated H3K4me3 and the fate of double-stranded breaksCELL RESEARCHOAAI
CELL RESEARCHIF25.9
OAAI分享收藏Connectivity maps for biosimilar drug discovery in venoms: The case of Gila Monster Venom and the anti-diabetes drug Byetta®Toxicon
ToxiconIF0
PREAI
分享收藏
查看更多内容