.png){kind=icon}
返回
Neurocardiology: Structure-Based Function
.png){kind=icon}
PRE
AI
DOI：10.1002/cphy.c150046.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Cardiac control is mediated via a series of reflex control networks involving somata in the (i) intrinsic cardiac ganglia (heart), (ii) intrathoracic extracardiac ganglia (stellate, middle cervical), (iii) superior cervical ganglia, (iv) spinal cord, (v) brainstem, and (vi) higher centers. Each of these processing centers contains afferent, efferent, and local circuit neurons, which interact locally and in an interdependent fashion with the other levels to coordinate regional cardiac electrical and mechanical indices on a beat-to-beat basis. This control system is optimized to respond to normal physiological stressors (standing, exercise, and temperature); however, it can be catastrophically disrupted by pathological events such as myocardial ischemia. In fact, it is now recognized that autonomic dysregulation is central to the evolution of heart failure and arrhythmias. Autonomic regulation therapy is an emerging modality in the management of acute and chronic cardiac pathologies. Neuromodulation-based approaches that target select nexus points of this hierarchy for cardiac control offer unique opportunities to positively affect therapeutic outcomes via improved efficacy of cardiovascular reflex control. As such, understanding the anatomical and physiological basis for such control is necessary to implement effectively novel neuromodulation therapies. (C) 2016 American Physiological Society.
Keyword:
INTRINSIC CARDIAC NEURONS
SPINAL-CORD STIMULATION
VAGUS NERVE-STIMULATION
CHRONIC HEART-FAILURE
REFRACTORY VENTRICULAR-ARRHYTHMIAS
NONMEDULLATED VAGAL AFFERENTS
CHRONIC MYOCARDIAL-INFARCTION
SA-NODAL PARASYMPATHECTOMY
ATRIAL GANGLIONATED PLEXUS
BRAIN-STEM PROJECTIONS
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
5.2
论文数:
954
被引数:
8.4K
机构
引用论文
.png){kind=icon}
Discrepancy Risk Model Selection Test Theory for Comparing Possibly Misspecified or Nonnested Models
PREAI
分享收藏Bilinear elastically deformable models with application to 3D face and facial expression recognition
PREAI
分享收藏
查看更多内容