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Neurodevelopment, GABA System Dysfunction, and Schizophrenia
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DOI：10.1038/npp.2014.95.png)
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The origins of schizophrenia have eluded clinicians and researchers since Kraepelin and Bleuler began documenting their findings. However, large clinical research efforts in recent decades have identified numerous genetic and environmental risk factors for schizophrenia. The combined data strongly support the neurodevelopmental hypothesis of schizophrenia and underscore the importance of the common converging effects of diverse insults. In this review, we discuss the evidence that genetic and environmental risk factors that predispose to schizophrenia disrupt the development and normal functioning of the GABAergic system.
Keyword:
DORSOLATERAL PREFRONTAL CORTEX
MATERNAL IMMUNE ACTIVATION
MESSENGER-RNA EXPRESSION
GLUTAMIC-ACID DECARBOXYLASE
NEUROTROPHIC FACTOR VAL66MET
GAMMA-AMINOBUTYRIC-ACID
CORTICAL GABAERGIC INTERNEURONS
BDNF VAL(66)MET POLYMORPHISM
CB1 CANNABINOID RECEPTORS
COMPLEX BRAIN DISORDERS
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