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Neuronal activation sequences in lateral prefrontal cortex encode visuospatial working memory during virtual navigation
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DOI：10.1038/s41467-024-48664-9.png)
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Working memory (WM) is the ability to maintain and manipulate information 'in mind'. The neural codes underlying WM have been a matter of debate. We simultaneously recorded the activity of hundreds of neurons in the lateral prefrontal cortex of male macaque monkeys during a visuospatial WM task that required navigation in a virtual 3D environment. Here, we demonstrate distinct neuronal activation sequences (NASs) that encode remembered target locations in the virtual environment. This NAS code outperformed the persistent firing code for remembered locations during the virtual reality task, but not during a classical WM task using stationary stimuli and constraining eye movements. Finally, blocking NMDA receptors using low doses of ketamine deteriorated the NAS code and behavioral performance selectively during the WM task. These results reveal the versatility and adaptability of neural codes supporting working memory function in the primate lateral prefrontal cortex.
Keyword:
NEURAL SEQUENCES
FRONTAL-CORTEX
NMDA RECEPTORS
VARIABILITY
TIME
HIPPOCAMPUS
MECHANISMS
PATTERNS
DISTANCE
MODEL
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15.7
论文数:
9.4W
被引数:
91.2W
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Ketamine disrupts naturalistic coding of working memory in primate lateral prefrontal cortex networks.png)
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