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Neuronal size and geometry shape brain function
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DOI：10.1016/j.tcb.2026.05.002.png)
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Abstract
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Neuronal size varies across evolution, diseases, and brain regions. It has long been regarded as a descriptor, not a driver of function. Using triploid Xenopus, Liu et al. show that neuronal enlargement remodels neurite geometry, reduces proliferation, increases phospho-extracellular signal regulated kinase (pERK) responses, and alters behavior, linking cellular scaling to brain function.
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