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Neutrophil-mediated macrophage responses to biodegradable magnesium and zinc implants

delete2026-07-09
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OA
AI
J
Jiannan Zhou
Y
Yili Zhao
W
Wenyan Zhan
Q
Qingyang Yan
C
Chen Zhu
X
Xiaokun Yang
A
An Li
J
Jingtao Dai *
Y
Yageng Li *
P
Ping Li *
DOI：10.1016/j.jma.2026.102186delete
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Abstract

Abstract

En 中文
• Single-cell RNA sequencing reveals immune landscapes of Mg, Zn and Ti implants. • Mg implants trigger acute inflammation via neutrophil-Cers6+ macrophage crosstalk. • Zn implants promote bone remodeling via neutrophil-Ccl3+ macrophage interactions. • LGALS9-CD45 and SEMA4D-PLXNB2 axes govern material-specific immunity.
Keywords:
Biomaterials
Metals
Bone
Magnesium
Zinc
Titanium

Journal

Journal of Magnesium and Alloys cover
Journal of Magnesium and Alloys
IF:
13.8
Papers:
2.1K
Citations:
1.6W

Organization

G
guangzhou medical university
Scholars:
5.0K
Papers: 1.3K
Citations: 0
S
southern medical university
Scholars:
1.1W
Papers: 2.9K
Citations: 5
U
university of science and technology beijing
Scholars:
1.1W
Papers: 4.0K
Citations: 2
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