Nonneuronal contributions to synaptic function

Ritchy Hodebourg

doi:10.1016/j.neuron.2025.04.004

2025-04-30

PRE

DOI：10.1016/j.neuron.2025.04.004

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摘要

En 中文

突触是优雅整合的信号枢纽，包含经典的突触成分、神经元突触前和突触后结构，以及神经丛的其他组分，包括突触周星形胶质细胞、细胞外基质蛋白，以及小胶质细胞和少突胶质细胞。这些多组分枢纽内的信号传导对突触功能至关重要，并且在神经精神疾病中常被破坏。我们回顾了精炼了我们对环境刺激如何塑造突触内信号传导和突触可塑性的理解的数据。我们提出了工作模型，整合了关于不同细胞类型如何调控由成瘾药物引发的突触功能及其障碍的已知知识。虽然这些工作模型整合了现有发现，但它们受到新技术的需求限制。相应地，我们提出了改进试剂和实验方法的方向，以更好地探查突触周生态系统内细胞间信号传导如何创造建立和维持适应性及不良行为所必需的突触可塑性。

Keyword:

astroglia

synapse

extracellular matrix

oligodendrocyte

microglia

addiction

期刊

Neuron

IF:

论文数:

1.4W

被引数:

9.9W

机构

Medical University of South Carolina

学者数:

1.6W

论文数: 1.3W

被引数: 1.4W

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