.png){kind=icon}
返回
Notes on stochastic (bio)-logic gates: computing with allosteric cooperativity
.png){kind=icon}
OA
AI
DOI：10.1038/srep09415.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Recent experimental breakthroughs have finally allowed to implement in-vitro reaction kinetics (the so called enzyme based logic) which code for two-inputs logic gates and mimic the stochastic AND (and NAND) as well as the stochastic OR (and NOR). This accomplishment, together with the already-known single-input gates (performing as YES and NOT), provides a logic base and paves the way to the development of powerful biotechnological devices. However, as biochemical systems are always affected by the presence of noise (e. g. thermal), standard logic is not the correct theoretical reference framework, rather we show that statistical mechanics can work for this scope: here we formulate a complete statistical mechanical description of the Monod-Wyman-Changeaux allosteric model for both single and double ligand systems, with the purpose of exploring their practical capabilities to express noisy logical operators and/or perform stochastic logical operations. Mixing statistical mechanics with logics, and testing quantitatively the resulting findings on the available biochemical data, we successfully revise the concept of cooperativity (and anti-cooperativity) for allosteric systems, with particular emphasis on its computational capabilities, the related ranges and scaling of the involved parameters and its differences with classical cooperativity (and anti-cooperativity).
Keyword:
BACTERIAL CHEMOTAXIS
ESCHERICHIA-COLI
LOGIC
ORGANIZATION
MODULARITY
NETWORKS
INPUTS
MODEL
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
3.9
论文数:
28.0W
被引数:
83.5W
机构
引用论文
Reduced -defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease.png)
GutOAAI
GutIF0
OAAI分享收藏
查看更多内容