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Novel enhancer activation non-restrictively followed a predefined framework in plastic vascular smooth muscle cells
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DOI：10.1016/j.yjmcc.2026.05.003.png)
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Abstract
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• Active enhancers existed in distinct maturation states, as reflected by the sequential and differential reductions of H3K4me1, H2A.Z and H3K27ac. • H2A.Z incorporated into chromatin after H3K4me1 modification and initiated H3K27ac modification that became stabilized later, suggesting a hit-and-stabilize model. • H2A.Z continued to incorporate into chromatin on each time of SMC transformation, thereby mediating continuous expansion of enhancer network in the plastic vascular SMCs.
Keywords:
enhancer activation
H2A.Z
H3K27ac
chromatin remodeling
vascular smooth muscle cells
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