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NUDT2 and A proteome-wide causal map of plasma proteins in osteoporosis
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DOI：10.1016/j.jare.2026.08.023.png)
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Abstract
En 中文
• Construction of a large-scale causal atlas linking the plasma proteome to osteoporosis. • Identification of two novel osteoporosis susceptibility loci (HOXC5 and HBQ1) via GWAS meta-analysis. • Revelation of three core pathological axes: WNT signaling, NUDT2-mediated metabolism, and pulmonary-bone crosstalk. • Characterization of NUDT2 as a druggable regulator of osteoprogenitor differentiation.
Keywords:
Osteoporosis
Proteome-wide Mendelian randomization
Plasma proteome
Therapeutic Targets
NUDT2
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13
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2.8K
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1.4W
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