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NUP62 promotes breast cancer progression and inhibits ferroptosis by stabilizing NRF2 in a KEAP1-dependent way

delete2026-03-26
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OA
AI
Z
Ziran Qiu
Y
Yu Lin
S
Shanzheng Chen
W
Wenqing Cao
J
Jun Yang
R
Rui Li
Y
Yuan Chen
X
Xiaoqing Yao
S
Senlin Fu
N
Na Jin *
DOI：10.1016/j.isci.2026.115484delete
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Abstract

Abstract

En 中文
• NUP62 is upregulated in breast cancer and correlates with a poor prognosis • NUP62 competitively binds KEAP1 to stabilize NRF2 and suppress ferroptosis • NUP62 knockdown enhances lipid peroxidation and induces ferroptosis in BC • Eribulin targets NUP62 to destabilize NRF2 and inhibit tumor growth in vivo
Keywords:
pharmacology
molecular biology
cancer

Journal

iScience cover
iScience
IF:
4.1
Papers:
4.6K
Citations:
4.1W

Organization

C
Chinese Academy of Medical Sciences and Peking Union Medical College
Scholars:
9.6K
Papers: 2.7K
Citations: 5.9W
L
Loudi Central Hospital
Scholars:
31
Papers: 14
Citations: 90
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