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Nutrient stress activates RAB5B-mediated autophagy to remodel the synaptic proteome

delete2026-07-31
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OA
AI
M
Melina Overhoff
L
Lotte Ickert
S
Sebastian Marten
A
Andrew Hill
F
Frederik Tellkamp
A
Ali Chitsaz
S
Saskia L. Ludwig
P
Philipp Antczak
F
Felix C. Koehler
R
Roman-Ulrich Müller
M
Marcus Krüger
N
Natalia L. Kononenko *
DOI：10.1016/j.celrep.2026.117766delete
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Abstract

Abstract

En 中文
• Nutrient withdrawal robustly remodels the synaptic proteome • Synaptic autophagy is induced independently of mTORC1 inhibition • RAB5B recruits ATG16L1 machinery during nutrient stress • Dynein-dependent trafficking supports synaptic autophagosome formation
Keywords:
autophagy
synapse
proteostasis
trafficking
endosomes
nutrient stress
CP: neuroscience
CP: metabolism
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Journal

Cell Reports cover
Cell Reports
IF:
6.9
Papers:
1.7W
Citations:
10.2W

Organization

U
University of Cologne
Scholars:
2.9W
Papers: 2.1W
Citations: 2.4W
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