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Obesity in Classic Congenital Adrenal Hyperplasia: Mechanisms, Complications and Management

delete2026-05-10
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J
Jialin Mu *
Y
Yue Li
M
Meng Sun
Y
Yulin Li
P
Panpan Li
H
Hui Zou *
DOI:10.1111/cen.70155delete
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Abstract

Abstract

En 中文
Classic congenital adrenal hyperplasia (CCAH) is an autosomal recessive genetic disorder primarily caused by 21-hydroxylase deficiency. Although the survival rate of patients has significantly improved with glucocorticoid replacement therapy, long-term use of supraphysiological doses and multiple factors inherent to the disease itself have led to obesity becoming a common metabolic complication in CCAH patients. The mechanism of obesity in CCAH patients is complex and involves multiple factors related to both treatment and the disease itself. This article provides a narrative review of the incidence, influencing factors, related complications and treatment management strategies of obesity in CCAH patients, with the aim of offering comprehensive management recommendations for clinical practice.
Keywords:
complications
congenital adrenal hyperplasia
factors
management
obesity
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Clinical Endocrinology cover
Clinical Endocrinology
IF:
2.4
Papers:
7.4K
Citations:
1.3W

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J
jinan maternal and child care hospital
Scholars:
6
Papers: 2
Citations: 0
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