Olfactory Function in Primary Open-Angle Glaucoma Patients

Konstantin Gugleta

doi:10.1055/s-0029-1245198

Olfactory Function in Primary Open-Angle Glaucoma Patients

2010-04-20

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DOI：10.1055/s-0029-1245198

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Purpose: The aim of this study was to assess the olfactory function of primary open-angle glaucoma patients. Patients and Methods: We analyzed odour threshold, identification, and discrimination in 30 primary open-angle glaucoma patients and 30 age- and gender-matched healthy control subjects. The Sniffin' Sticks test battery was applied sequentially on both sides, scores of two nostrils were averaged and means were compared with Mann-Whitney U-test between the groups. Results: Scores for odour threshold were 5.9 +/- 2.2 and 7.4 +/- 2.1 in glaucoma and control group, respectively (p = 0.01), for odour discrimination 10.5 +/- 2.0 and 10.8 +/- 1.6 (p = 0.65), and for odour identification 11.8 +/- 2.1 and 10.6 +/- 1.6 (p = 0.008). Comparing within glaucoma group between those with (n = 18) and without history (n = 12) of cold hands and feet, the former had significantly better odour threshold scores, 6.6 +/- 1.5, than the latter, 4.8 +/- 2.6 (p = 0.036); no difference in other two olfactory modalities were detected. Conclusion: Changes of olfactory function have been described in neurodegenerations such as Alzheimer and Parkinson diseases. Complex alterations of olfactory performance seem to be present in POAG patients as well.

Keyword:

olfaction

sniffing sticks test

glaucoma

Olfactory Function in Primary Open-Angle Glaucoma Patients

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