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Oncogene addiction
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DOI：10.1158/0008-5472.CAN-07-3293.png)
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摘要
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Cancer cells contain multiple genetic and epigenetic abnormalities. Despite this complexity, their growth and survival can often be impaired by the inactivation of a single oncogene. This phenomenon, called oncogene addiction, provides a rationale for molecular targeted therapy. The efficacy of this strategy requires novel methods, including integrative genomics and systems biology, to identify the state of oncogene addiction (i.e., the Achilles heel) in specific cancers. Combination therapy may also be required to prevent the escape of cancers from a given state of oncogene addiction.
Keyword:
MULTISTAGE CARCINOGENESIS
CELL CIRCUITRY
EGF RECEPTOR
BCR-ABL
CANCER
RESISTANCE
MUTATION
DISORDERS
BREAST
MYC
期刊
IF:
16.6
论文数:
10.9W
被引数:
11.9W
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引用论文
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