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Open mass spectrometry search algorithm
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DOI：10.1021/pr0499491.png)
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摘要
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Large numbers of MS/MS peptide spectra generated in proteomics experiments require efficient, sensitive and specific algorithms for peptide identification. In the Open Mass Spectrometry Search Algorithm (OMSSA), specificity is calculated by a classic probability score using an explicit model for matching experimental spectra to sequences. At default thresholds, OMSSA matches more spectra from a standard protein cocktail than a comparable algorithm. OMSSA is designed to be faster than published algorithms in searching large MS/MS datasets.
Keyword:
protein identification
algorithm
bioinformatics
mass spectrometry
proteomics
significance testing
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