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Opposite network patterns of integration-segregation in psychedelic and sedated states of consciousness
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DOI：10.1016/j.celrep.2026.117830.png)
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Abstract
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• Psychedelic and sedative states are associated with opposite brain network patterns • Three complementary metrics show consistent shifts in integration-segregation features • The mirror-image pattern spans global, hierarchical, and network spatial scales • A linear mixed-effects model confirms robustly divergent trajectories
Keywords:
consciousness
integration
segregation
fMRI
functional connectivity
complexity
sedation
anesthesia
sleep
psychedelics
CP: neuroscience
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