Optimization in seeded cooling crystallization: A parameter estimation and dynamic optimization study

doi:10.1016/j.cep.2007.02.020

2007-11-01

PRE

Seyed Mostafa Nowee Baghban

Ali Abbas

José A. Romagnoli *

DOI：10.1016/j.cep.2007.02.020

原文链接

原文求助

摘要

En 中文

In this solution crystallization study, a population balance model that predicts the crystal size distribution (CSD) is used for targeting, by optimization, the product mean size and the coefficient of variation of the final CSD. The model is robust over a wide range of conditions and predicts the effects of heating during a batch since the kinetics of dissolution have been identified and incorporated into the model. The dynamic temperature profile and the initial seed size distribution are optimized while the initial seed induction time is conferred through knowledge of saturation conditions. This is quite a highly developed method that provides a systematic approach towards optimal operation. Results from optimizations under different objective functions are presented and validated experimentally. (c) 2007 Elsevier B. V. All rights reserved.

Keyword:

crystallization

cooling

seeding

CSD

nucleation

growth

parameter estimation

dynamic optimization

AI总结

对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。

期刊

Chemical Engineering and Processing and Process Intensification

IF:

3.9

论文数:

5.7K

被引数:

1.4W

机构

暂无机构信息

引用论文

DETECT-dual energy transmission estimation CT-for improved attenuation correction in SPECT and PET

IEEE Transactions on Nuclear Science

IF0

1998-06-01

PREAI

M.J. Guy; I.A. Castellano-Smith; M.A. Flower; G.D. Flux; R.J. Ott; D. Visvikis

SOBER

Proceedings of the 10th European software engineering conference held jointly with 13th ACM SIGSOFT international symposium on Foundations of software engineering

IF0

2005-09-01

PREAI

Chao Liu; Xifeng Yan; Long Fei; Jiawei Han; Samuel P. Midkiff

Assessing the acceptability, service delivery requirements, and use-effectiveness of the diaphragm in Colombia, Philippines, and Turkey

Contraception

IF0

2001-05-01

PREAI

Aysen Bulut; Nuriye Ortayli; Karin Ringheim; Jane Cottingham; Timothy M.M. Farley; Alexander Peregoudov; Carol Joanis; Susan Palmore; Martha Brady; Juan Diaz; Gabriel Ojeda; Rebecca Ramos

A practical guide to pharmaceutical analyses using X-ray powder diffraction

Powder Diffraction

IF0

2019-04-15

PREAI

T. G. Fawcett; S. Gates-Rector; A. M. Gindhart; M. Rost; S. N. Kabekkodu; J. R. Blanton; T. N. Blanton

Effects of initial concentration and seeding procedure on crystallisation of orthorhombic paracetamol from ethanolic solution

INTERNATIONAL JOURNAL OF PHARMACEUTICS

IF5.2

2003-07-09

PREAI

Al-Zoubi, N; Malamataris, S