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Optimized temporal pattern of brain stimulation designed by computational evolution
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DOI：10.1126/scitranslmed.aah3532.png)
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Brain stimulation is a promising therapy for several neurological disorders, including Parkinson's disease. Stimulation parameters are selected empirically and are limited to the frequency and intensity of stimulation. We varied the temporal pattern of deep brain stimulation to ameliorate symptoms in a parkinsonian animal model and in humans with Parkinson's disease. We used model-based computational evolution to optimize the stimulation pattern. The optimized pattern produced symptom relief comparable to that from standard high-frequency stimulation (a constant rate of 130 or 185 Hz) and outperformed frequency-matched standard stimulation in a parkinsonian rat model and in patients. Both optimized and standard high-frequency stimulation suppressed abnormal oscillatory activity in the basal ganglia of rats and humans. The results illustrate the utility of model-based computational evolution of temporal patterns to increase the efficiency of brain stimulation in treating Parkinson's disease and thereby reduce the energy required for successful treatment below that of current brain stimulation paradigms.
Keyword:
SUBTHALAMIC NUCLEUS STIMULATION
DISEASE RATING-SCALE
PARKINSONS-DISEASE
OSCILLATORY SYNCHRONIZATION
NEURONAL-ACTIVITY
GENERATOR REPLACEMENT
PALLIDAL STIMULATION
TREMOR AMPLITUDE
BASAL GANGLIA
BRADYKINESIA
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分享收藏Minimal clinically important change on the Unified Parkinson's Disease Rating Scale统一帕金森病评分量表的最小临床重要变化.png)
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