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Optimizing cefazolin dosing for central nervous system infections: insights from population pharmacokinetics and Monte Carlo simulations

delete2025-05-20
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OA
AI
C
C. Tyler Pitcock
D
David S. Burgess
K
Katie B. Olney *
DOI：10.1128/aac.01857-24delete
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Abstract

Abstract

En 中文
Recent studies suggest that cefazolin represents an appropriate treatment option for methicillin-susceptible Staphylococcus aureus (MSSA) central nervous system (CNS) infections. Monte Carlo simulations were used to evaluate specific cefazolin dosing regimens to identify the optimal dosing strategy to ensure adequate probability of target attainment for treatment of MSSA CNS infections.
Keywords:
pharmacokinetic
pharmacodynamic
cefazolin
CNS

Journal

Antimicrobial Agents and Chemotherapy cover
Antimicrobial Agents and Chemotherapy
IF:
4.5
Papers:
2.3W
Citations:
6.2W

Organization

D
DUKE UNIV HOSP
Scholars:
104
Papers: 114
Citations: 14
U
Univ Kentucky
Scholars:
1.1K
Papers: 744
Citations: 152
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