arrow
返回

Optimizing sample size for supervised machine learning with bulk transcriptomic sequencing: a learning curve approach

delete2025-03-12
delete0
delete
OA
AI
Y
Yunhui Qi
X
Xinyi Wang
L
Li‐Xuan Qin *
DOI:10.1093/bib/bbaf097delete
delete原文链接
delete原文求助
delete分享
delete收藏
摘要

摘要

En 中文
利用转录组学数据进行准确的样本分类对于推动个性化医学至关重要。实现这一目标需要确定一个合适的样本量,以确保分类精度,同时避免不必要地分配过多资源。现有的样本量计算方法依赖的假设和算法可能与监督式机器学习技术不匹配。为解决这一关键的方法学差距,我们提出了一种新的计算方法,通过采用数据增强策略并结合学习曲线拟合,建立了准确率与样本量的关系。我们基于一系列评估指标,综合考虑了多种数据特征和算法配置,全面评估了该方法在miRNA和RNA测序数据上的性能。为促进易用性和可重复性,我们方法的Python和R实现代码已发布在GitHub上。该方法的部署将显著促进机器学习在转录组学研究中的应用,并加速其转化为用于个性化治疗的临床实用分类器。
Keyword:
sample size
machine learning
transcriptomics
bulk sequencing

期刊

Briefings in Bioinformatics 封面图
Briefings in Bioinformatics
IF:
7.7
论文数:
5.8K
被引数:
2.7W

机构

M
Mem Sloan Kettering Canc Ctr
学者数:
1.9K
论文数: 901
被引数: 450
引用论文

引用论文

err分享
err收藏
Engineering Psychology and Human Performance
err
IF0
err2021-08-31
err0
PREAI
errChristopher D. Wickens; William S. Helton; Justin G. Hollands; Simon Banbury
err分享
err收藏
How large a training set is needed to develop a classifier for microarray data?
err2008-01-02
err104
errOAAI
errDobbin, Kevin K.; Zhao, Yingdong; Simon, Richard M.
err分享
err收藏
The functions of animal microRNAs
err2004-09-15
err0
PREAI
errVictor Ambros
err分享
err收藏
err分享
err收藏
err分享
err收藏
MicroRNAs
errCell
IF0
err2004-01-01
err0
errOAAI
errDavid P Bartel
err分享
err收藏
Opportunities and obstacles for deep learning in biology and medicine生物学和医学深度学习的机遇和障碍
err2018-04-04
err1.3K
errOAAI
errChing, Travers; Himmelstein, Daniel S.; Beaulieu-Jones, Brett K.; Kalinin, Alexandr A.; Do, Brian T.; Way, Gregory P.; Ferrero, Enrico; Agapow, Paul-Michael; Zietz, Michael; Hoffman, Michael M.; Xie, Wei; Rosen, Gail L.; Lengerich, Benjamin J.; Israeli, Johnny; Lanchantin, Jack; Woloszynek, Stephen; Carpenter, Anne E.; Shrikumar, Avanti; Xu, Jinbo; Cofer, Evan M.; Lavender, Christopher A.; Turaga, Srinivas C.; Alexandari, Amr M.; Lu, Zhiyong; Harris, David J.; DeCaprio, Dave; Qi, Yanjun; Kundaje, Anshul; Peng, Yifan; Wiley, Laura K.; Segler, Marwin H. S.; Boca, Simina M.; Swamidass, S. Joshua; Huang, Austin; Gitter, Anthony; Greene, Casey S.
err分享
err收藏
学者 查看更多内容