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Optimizing the composition and size of perfluorocarbon nanodroplets to balance their acoustic activation and blood circulation time
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DOI：10.1016/j.jconrel.2026.115222.png)
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Abstract
En 中文
• Functional stability depends more strongly on core retention than particle size. • Shell mechanics govern PCND deformability and biodistribution. • Increasing PCND size enhances pulmonary retention and limits tolerability. • Stable and deformable PCND show enhanced tumor accumulation. • Tumor accumulation is jointly governed by formulation design and tumor vasculature.
Keywords:
Ultrasound
Phase-change nanodroplets
Acoustic droplet vaporization
Pharmacokinetics
Tumor accumulation
Dose tolerability
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