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Optofluidic Flow-Through Biosensor Sensitivity - Model and Experiment
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DOI：10.1109/JLT.2021.3061872.png)
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摘要
En 中文
We present a model and simulation for predicting the detected signal of a fluorescence-based optical biosensor built from optofluidic waveguides. Typical applications include flow experiments to determine pathogen concentrations in a biological sample after tagging relevant DNA or RNA sequences. An overview of the biosensor geometry and fabrication processes is presented. The basis for the predictive model is also outlined. The model is then compared to experimental results for three different biosensor designs. The model is shown to have similar signal statistics as physical tests, illustrating utility as a pre-fabrication design tool and as a predictor of detection sensitivity.
Keyword:
Optical waveguides
Fluorescence
Biosensors
Photonics
Biological system modeling
Predictive models
Transmission line matrix methods
Anti-resonant reflecting optical waveguides (ARROW)
integrated waveguides
model design
optofluidics
predictive simulation
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期刊
IF:
4.8
论文数:
1.7W
被引数:
3.8W
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引用论文
Optofluidic Lab-on-a-Chip Fluorescence Sensor Using Integrated Buried ARROW (bARROW) Waveguides使用集成掩埋箭头 (bARROW) 波导的光流控芯片实验室荧光传感器OAAI
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