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Optogenetics in primates: a shining future?

delete2013-07-01
delete75
PRE
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A
Annelies Gerits
W
Wim Vanduffel *
DOI:10.1016/j.tig.2013.03.004delete
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摘要

摘要

En 中文
To understand the functional role of specific neurons in micro- and macro-brain circuitry, health, and disease, it is critical to control their activity precisely. This ambitious goal was first achieved by optogenetics, allowing researchers to increase or decrease neural activity artificially with high temporal and spatial precision. In contrast to the revolution optogenetics engendered in invertebrate and rodent research, only a few studies have reported optogenetic-induced neuronal and behavioral effects in primates. Such studies are nonetheless critical before optogenetics can be applied in a clinical setting. Here, we review the state-of-the-art tools for performing optogenetics in mammals, emphasizing recent neuronal and behavioral results obtained in nonhuman primates.
Keyword:
optogenetics
nonhuman primates
behavior
bioengineered opsins
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期刊

Trends in Genetics 封面图
Trends in Genetics
IF:
16.3
论文数:
3.4K
被引数:
1.5W

机构

K
KU Leuven
学者数:
5.7W
论文数: 5.2W
被引数: 8.1W
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