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P5CS represses tumor progression via inhibiting assembly of 48S pre-translation initiation complex
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DOI：10.1016/j.devcel.2026.05.011.png)
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Abstract
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• P5CS preferentially binds the 5′ UTR of mRNAs in an enzyme-independent manner • P5CS contains an RNA-binding motif within amino acids 150–159 of its kinase domain • P5CS blocks pre-translational 48S assembly via mRNA 5′ UTR and eIF3a/3d interactions • P5CS RNA binding suppresses global protein synthesis and cancer cell proliferation
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